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Candesartan is an angiotensin 2 receptor blocker. The mechanism of action of candesartan is as an angiotensin 2 receptor antagonist.
Candesartan is a synthetic, benzimidazole-derived angiotensin ii receptor antagonist prodrug with antihypertensive activity. candesartan selectively competes with angiotensin ii for the binding of the angiotensin ii receptor subtype 1 (at1) in vascular smooth muscle, blocking angiotensin ii-mediated vasoconstriction and inducing vasodilatation. In addition, antagonism of at1 in the adrenal gland inhibits angiotensin ii-stimulated aldosterone synthesis and secretion by the adrenal cortex; sodium and water excretion increase, followed by a reduction in plasma volume and blood pressure.
synonyms: 2-ethoxy-3-[[4-[2-(2h-tetrazol-5-yl) phenyl] phenyl] methyl] benzimidazole-4-carboxylic acid
cas number: 139481-59-7, mol. Formula: c24h20n6o3, mol.weight: 440.45
candesartan is a colourless crystalline solid powder. It is soluble in water with melting range of 183°cto 185°c.
Standard: offered of pharmaceutical grade bpuspep
packing: offered in export worthy packing of 25 kilos or as per our customer requirements