Anti Inflammatory Tablets

Nimesulide I.P. 100mg & Paracetamol I.P. 500mg Tablets
Pharmacodynamic
Nimesulide is an inhibitor of cyclooxygenase so it inhibits synthesis of destructive prostaglandins and spares cytoprotective prostaglandins. Nimesulide appears to exert its effects also through a variety of other mechanisms and involves interference with the production action of mediators other than prostaglandins such as enzymes, toxic oxygen derivatives, cytokines, platelet activating factor and histamine.
Paracetamol - is a valuable central analgesic but weak peripheral anti-inflammatory agent and exhibits agent and exhibits antipyretic action.
Pharmacokinetic
Nimesulide - after oral administration the peak plasma concentrations of 1.98-9.85 mgL are achieved within 1 to 3 hrs. Nimesulide undergoes extensive metabolism and is eliminated through urine and feces.
Paracetamol is rapidly and completely absorbed from gastrointestinal tract. Peak plasma is achieved within 0.5 to 2 hrs. the drug is metabolized in the liver. 90% of the drug is excreted through urine.
Precautions and Warnings
Patients hypersensitive to aspirin may also be sensitive to paracetamol or nimesulide. Mild bronchospastic reactions with paracetamol have been reported in some aspirin sensitive asthroatics
The combination should be used with caution in patients with renal or hepatic impairment.
Dosage and administration: Nepar can be administered orally at a dosage of 1 tablet twice daily or as prescribed by the physician
Pregnancy & Lactation: The use of SparNim Plus is not recommended during pregnancy and lactation