AmBisome is indicated for presumed fungal infection in febrile neutropenic patients, Cryptococcal Meningitis in HIV-infected patients, treatment of Aspergillus species, Candida species andor Cryptococcus species infections refractory to amphotericin B deoxycholate, or in patients where renal impairment or unacceptable toxicity precludes the use of amphotericin B deoxycholate, treatment of visceral leishmaniasis; in immunocompromised patients with visceral leishmaniasis treated with AmBisome, relapse rates were high following initial clearance of parasites.