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Agomelatine is the first antidepressant to increase melatonin activity directly. It does this by acting like melatonin at the target sites where melatonin works. (These are known as the melatonin receptors). By increasing melatonin activity, agomelatine also directly increases activity of noradrenaline and dopamine.Agomelatine improves sleep quality and efficacy and treats insomnia. This compound also enhances neuroplasticity and neurogenesis in the hippocampus and prefrontal cortex.