Adapalene ingredient Skin Cream helps to treat acne. Decrease the number of acne pimples and quickly heals pimples to develop. Adapalene cream works by affecting the growth of cells and decreasing swelling and inflammation. How to Use Adapalene Cream Apply thin layer on your skin once daily at bedtime as directed by your doctor. Use cotton swab can be used to apply the solution. Wash your hands before and after applying this medication. It takes up to 8-12 weeks to notice results after using this cream. Use it daily in order to get the most benefit from it.