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Contact Supplier5-MeO-DMT (5-methoxy-N,N-) is a powerful and relatively obscure psychedelic and entheogen of the tryptamine class. It is found in a wide variety of plant species, as well as in the venom of a single psychoactive toad species (Bufo Alvaris). Like its close relatives DMT and bufotenin (5-HO-DMT), it has been used as an entheogen by South American shamans for thousands of years.[1] In modern times, however, it is primarily acquired in its synthetic powder form through the use of online research chemical vendors. When taken as a drug in its purified or synthetic form, 5-MeO-DMT is vaporized, insufflated, or injected and is active at a dose of as little as 2 mg. 5-MeO-DMT is active orally when taken with an MAOI, but according to numerous reports this combination often tends to be extremely unpleasant and has a strong body load. 5-MeO-DMT or 5-methoxy-N,N-is a ring-substituted indole molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to a terminal amine group via an ethyl side chain. 5-MeO-DMT is substituted at R5 of its indole heterocycle with a methoxy (MeO) functional group CH3O�; it also contains two methyl groups CH3- bound to the terminal amine RN of its tryptamine backbone (DMT). 5-MeO-DMT is the N-substituted methyl homologue of 5-MeO-MiPT, although it radically differs in its effects.