Avanafil is a Phosphodiesterase enzyme inhibitor having 100 times more selectivity towards Phosphodiesterase type 5 (PDE 5) than other Phosphodiesterase types. Phosphodiesterase type 5 (PDE5) is an enzyme which is responsible for the breakdown of cGMP in the penile tissue (corpus cavernosum). During sexual stimulation, nerve endings and endothelial cells release nitric oxide which triggers the cGMP production in smooth muscle cells of the . cGMP dilates penile blood vessels resulting in improved blood flow to the causing erection. Avanafil inhibits PDE-5, thereby enhancing the concentration of cGMP and thus it improves the erectile dysfunction.

Avanafil is a Phosphodiesterase enzyme inhibitor having 100 times more selectivity towards Phosphodiesterase type 5 (PDE 5) than other Phosphodiesterase types. Phosphodiesterase type 5 (PDE5) is an enzyme which is responsible for the breakdown of cGMP in the penile tissue (corpus cavernosum). During sexual stimulation, nerve endings and endothelial cells release nitric oxide which triggers the cGMP production in smooth muscle cells of the . cGMP dilates penile blood vessels resulting in improved blood flow to the causing erection. Avanafil inhibits PDE-5, thereby enhancing the concentration of cGMP and thus it improves the erectile dysfunction.