NIMISH PHARMA & SURGICALS

MG Road, Pondicherry

We are engaged in the supplying Anti-Rabies Serum that is a sterile; non-pyrogenic solution apt for intra-muscular administration. This Serum contains antiviral substances which are procured from the blood serum of vigorous equines that have been immunized against rabies vaccination. Additionally, it also consists of anti-microbial agent known as cresol. Indications : Patients at risk of being exposed to rabies Contact with a rabid animal Contra-Indication : This Serum should be used with extreme caution with subject to history of allergic symptoms, hypersensitivity, or any other kind of allergic conditions. Warning and precaution : We recommend a skin test before applying Anti-Rabies Serum. This test consists of an intra-dermal injection with a 1:10 dilution of Rabies antiserum (0.1 ml) on the outside of the forearm so as to attain an orange ring type appearance (3 mm diameter induration). An equivalent intra-dermal injection of physiological saline solution is used as control. There should be a through observation made 15 minutes after intra-dermal injection is consumed which is considered to be positive; if erythema (>6 mm), local oedema or a systemic reaction is observed and the control shows no such dermal reaction. Advice : This serum is not itself a treatment but should be consumed in conjunction with rabies vaccine. A positive test result is not a formal contra-indication for the use of serotheraphy. Herein, this serum should be applied only after ensuring the ability to overcome the anaphylactic shock. A negative test result is not guarantee for the absence of an immediate allergic reaction. Considering the risk associated with rabies, pregnant women can be provided with this serum Why our Anti-Rabies Serum? Completely purified equine rabies immunoglobulin Safe to consume Highly effective Affordable Treatment procedure : At first, scratches and bite wounds that may be contaminated with harmful rabies virus should be thoroughly washed with anti-septic soap and water. Immediately, rabies immune serum should be injected as soon as possible. For prevention, immunoglobulin- vaccine treatment is recommended. The suggested dose is 40 I.U./KG of body weight. If structurally feasible, larger quantity of the dose should be infiltrated around the wounds. The remainder should be administered intramuscularly (into the gluteal region) in a single dose. Adverse Effects : Immediate anaphylactoid reactions : Dyspnoea Hypotension Urticaria Delayed reactions consist of Inflammatory reaction Fever Pruritis Rash Urticaria Adenopathy Arthralagia. Storage : Store at a temperature between +2 o C and +8 o C in a refrigerator, DO NOT FREEZE. Presentation : Vials containing 1500 I.U. (5 ml)

We provide Anti-Snake Venom that is a sterile preparation containing equine immunoglobulin fragments F (ab') 2. The antitoxic equine immunoglobulin and its derivatives are acquired from the serum of healthy equines immunized against venoms of different species of snakes. Composition : The Anti-Snake Venom is constituted in freeze dried powder and in liquid form. Herein, the dried powder is reconstituted with 10ml of sterile water for injection IP, which ultimately dissolves into transparent colorless or pale yellow liquid. Each ml of this vial can potentially neutralize the venom of hard hitting snakes. After effects of snake bite : Cobra or Krait Staggering gait Blurred vision Difficulty in speaking Nausea and vomiting Drooping of head Creeping paralysis of muscles of eyelids Predominance of neurotoxins Death due to respiratory failure Russell's viper and saw scaled viper Persistent pain and swelling of the bitten limb Discharge of blood from the bite site Necrosis and blister formation Severe internal and external hemorrhage General vascular injury Vomiting may occur Death that results from cardiovascular shock or renal failure Dosage : For adults: 0.5mg of 1:1000 For children: 0.01mg/kg body weight of adrenaline I/M Reactions : Urticarial Fever Itching Nausea Chills or rigor Diarrhea Vomiting Abdominal cramps Hypotension Tachycardia Angioedema Bronchospasm Protection against anaphylactic reaction : For adults : 100mg of hydrocortisone and 10mg of H1 antihistamine can be given I/V For children : 0.2mg/kg of antihistamine I/V and 2mg/kg of hydrocortisone I/V If the patient�s condition has not improved or it gets worsening, a second dose is recommended of0.5 mg of adrenaline 1:1000 IM may be given. In case of hypertension or hemodynamic instability the patient should be provided with I/V fluids. In case the patient started recovering, anti-venom can be restarted slowly for 10-15 minutes. The patient should be kept under closed observation afterwards the normal drip rate can be resumed. In case of Serum sickness, patient should be treated with oral antihistamines and corticosteroids. The dosage for adults is 5mg 6 hourly and for child is 0.7mg/kg/day. Storage This preparation should be stored in cool and dark place. Exposure to excessive heat should be strictly avoided. This preparation should not be stored for longer period of time and strictly restricted to freeze. 10 ml liquid vials should be stored between 2 o C and 8 o C. DO NOT FREEZE. Presentation 10 ml of the Anti-Snake Venom is available in glass container. Disposal Left over Anti-Venom and used empty container should be discarded as biomedical waste. Each ml has power of specifically neutralising the venoms of following species of snakes : 0.60 mg of dried Indian Cobra (Naja naja) venom 0.45 mg of dried Common Krait (Bangarus caeruleus) venom 0.60 mg of dried Russell's Viper (Vipera russelli) venom 0.45 mg of dried Sawscaled Viper (Echis carinatus) venom