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Enzymes are protein-biological catalysts that speed up chemical reactions in living organisms. Enzymes are fundamental to all biological processes. Typically enzymes bind a substrate in a well confined binding pocket which stabilizes the intermediate state that the substrate has to assume during its conversion into the product of the enzymatic reaction. Enzymes come in all shapes and forms and catalyze all biological processes, including protein synthesis and degradation, metabolic reactions, DNA synthesis and degradation, etc. Enzymes are prime drug targets in the pharmaceutical industry, because enzymes are frequently overactive and are relatively easy targets for small molecule inhibitor discovery.