Cologenesis Healthcare Pvt Ltd

Udayapatti, Salem, Tamil Nadu

Sterile Dry collagen sheet advantages :

• Ready to use transparent self adhesive and dry membrane that offers complete flexibility.
• Accelerates healing rate minimises dressing.
• Reduces scarring by depositing oriented and organised fibres
• Regulates the amount of collagenase expressed by keratinocytes.
• Reduces wound treatment costs by 40%

Sizes : 5x5 cms, 10 x 10 cms, 10 x 25 cms, 15 x 30 cms

Applications :

• Partial and full thickness wounds
• Pressure ulcers
• Venous Ulcers
• Chronic Vascular ulcer
• Diabetic ulcers
• Trauma wounds (abrasions, lacerations, second degree burns, skin tears)
• Surgical wounds (Donor sites, Grafts, Post moh's surgery, post laser surgery, paediatric and wound dehiscence)

Precautions

Collograft should be avoided for the patients Hypersensitive to collagen

Collograft-B is a dry collagen sheet, with non-adherant, Absorbant baking.It is used for effective management of moderate to heavy draining wounds.

Dry collagen sheet with Non adherant absorbant backing

• Purified Type-1 Collagen with Medical Grade PU Foam backing
• Flexible and tacky.
• Facilitates healing and hemostatic
• PU foam layer absorbs the exudes and keeps the wound free from contamination.
• Collagen is absorbed by the tissue in 6 to 10 days

Applications : All type of surface wounds Moderate to heavily draining wounds

Sizes Available : 5 x 5 cms, 10 x 10cms, 10 x 20 cms, 15 x 30 cms

Diacoll is a collagen Gentamicin sheet in the form of a sponge/transparent flim containing collagen and gentamicin sulphate. The collagen gentamicin implant is composed of highly purified type – I collagen obtained from bovine Tendon, which acts as a vehicle for the antimicrobial gentamicin. The collagen is derived from specifically controlled and certified animals and is highly purified to avoid any antiginicity. Gentamicin sulphate is a wide spectrum antibiotic that provides highly effective topical treatment in primary and secondary bacterial infections of the skin. Diacoll^TM is produced using the latest triple helix collagen technique to provide an optimum degree of flexibility and rigidity combined with the most predictable resorptive process.

Mechanism of Action :Diacoll^TM comprises of a collagen foam incoproated with gentamicin sulphate. When applied on teh wound the collagen foam acts as a vehicle for the antimicrobial gentamicin. Collagen is absorbed slowly by the tissue in 6 to 10 days after is application. The purpose of the implant is to provide a high concentration of local gentamicin at the site of implantation. The Diacoll^TM comes prepacked and sterile and is intended for single use only.

Indications :

• Diabetic foot ulcers.
• Orthopedic surgery.
• Treatment of osteomylitis and soft tissue infections.
• Abdominal wound infections.

Directions for use :

• In all cases standard established sterile surgical procedure must be observed.
• Diacoll^TM should be cut to the desired size to ideally extend 2-3mm beyond the edge of teh defect (s).
• The sheet once wet with blood tends to adapt extremely well to the bone/tissue walls.

Applications of Diacoll^TM implant on first day.

• Prepare the wound bed : Change and dispose of the old dressing in a safe, careful and appropriate manner.
• Accomplish appropriate wound debriment.
  • Irrigate the wound gently and carefully with sterile saline water until wound is free of debris, necrotic slough etc.
  • Gently blot wound edges and peri-wound margins dry.
• Apply Diacoll^TM
  • Take the appropriate size of the Diacoll^TM cut open the sterile pouch.
  • Cut the Diacoll^TM According to the shape of the wound and apply it to the wound surface.
  • When applied to the wound surface it tends of adapt extremely well to the bone / tissue walls.
• Wound care dressing : The area may be covered with gauze dressing if desired.

Precautions & Comments :

• Wounds may appear larger during first several days of treatment due to reduction of edema.
• An increase in drainage may be seen in the first several days of treatement.
• Treatment of the underlying conditons (Venous or arterial flow, external pressure as well as nturitional support should proceed concurrently with the use of Diacoll^TM.
• Avoid patient hypersensitive to collagen, Gentamicin.
• A transient burning sensation may be experienced by a small percentage of patients.

How supplied : Diacoll^TM implant is supplied in the following sizesin a gamma sterilized pouch. Sizes Available : 5cm x 5cm, 10cm x 10cm, 15cm x 30cm, 15cm x 65cm

Surgeons who treat chronic non-healing ulcers including diabetic ulcers and pressure ulcers etc., face a real challenge when it comes to the closure of the wounds due to inadequacies of conventional treatment protocols and complexities of ulcers. The result is catastrophic and traumatic. Quality of life suffers as many patients get into the stage of amputations especially in the case of diabetic foot ulcers. This is for this reason medicated bio-materials like Collofiber-MM play a very important role in the wound managment to alleviate the sufferings of millions of victims in this category. 

Collagen :

Collagen is an extra cellula matrix protein playing a major role in connective tissue. It is the most abundant protein in humans and performs multiple functions. Collagen as a bio-material and its role in wound management is a well documented subject. Collagen encourages wound healing through the deposition and organization of freshly formed fibers and granulation tissues in the wound bed and thus creating a very conducive environment to wound healing. 

Mupirocin – IP :

• Topical Mupirocin is very effective against S. Aureaus and this agent is invaluable in the eradication of staphylococci (oxford text book of medicine 3rd edn vol 1 p 526).
• Mupriocin is an antibiotic used in the treatment of various bacterial skin disorders (martindale, the extra pharmacopoeia 31st ednp 251)
• Mupirocin is an antibacterial agent and active against a wide range of gram +ve bacteria (PDR 55th EDN 2001 P 3075)

Metronidazole IP :

• Metronidazole topical cream is indicated in the treatment of gram-ve bacterial infections (PDR 55th edn 2001 p 291)
• Topical formulations of Metronidazole has proved effective in various skin disorders (martindale the extra pharmacopoeia p 624)
• Metronidazole is a member of the imidazole class of antibacterial agents and classified as an antibacterial (PDR 55th edn 2001 p 1115)
• Metronidazole has been used to treat anaerobic infections (oxfordtext book of medicine 3rd edv vol 1 p 575)

Description :

Collofibre – MM particles is primarily a type 1 collagen in lyophilized particle form with mupriocin USP 2% w/w and metronidazole IP 1% W/W of specified volumes. It is Gamma Sterillized and supplied in convenient pet containers collofibre-MM particles possessing good absorbing characteristics and is non-toxic non-allergenic and nonimmunogenic. 

Indications :

• Non healing uclers
• Diabetic foot ulcers
• Pressure Ulcers
• venous ulcers
• traumatic wounds
• surgical wounds
• infected wounds  

Application Methodology :

• Assess, Debride and clean the wound according to your protocols.
• Apply collofibre-MM particles sufficiently to cover the wound.
• With a heavily draining wound cover with a absorbent dressing and change as necessary.
• With a minimal draining wound cover with a secondary non absorbent dressing and change as required.
• Remove the secondary dressing daily as indicated by the amount of draining.
• If dressing is adhered to the wound irrigate with saline solution until dressing loosens and lift gently.
• Reapply collofibre-MM particles as before.

Precautions and warning :

• wounds may appear larger during the first several days of treatment due to the reduction of edema.
• An increase in drainage may be seen in teh several day of treatment.
• Treatment of the underlying conditions as well as nutritional support should proceed concurrently with the use of collofibre-MM
• Avoid topical agents like povidone iodine, H2O2 and sodium hypochloride for cleansing the wound as their toxicity level may hamper the new tissue growth.
• Collofibre-MM particles is a single use product which should not be resterilized.

Colloskin is a sterile collagen in sheet form and is crafted from bovine source. Colloskin's use has been widely accepted for biological wound dressing especially for burns. It is highly effective for patients including those with HIV and hepatitis infections. Indications :

• Ideal for Non-infective 2nd degree burns,
• Superficial & deep dermal burns
• For 3rd Degree burns as a temporary cover
• Traumatic loss of skin cover.
• Temperary wound cover in major open fracture wound
• Skin donor sites

Directions for Use :

• Throughly clean and denude areas to dliminate external contamination.
• Throughly debride infected wound.
• Take out the collagen sheet from the preserving medium and squeeze it to remove the excess preserving medium adhered to the colloskin.
• Take a trough and fill it with sterile saline water and rinse the colloskin throughly 2-3 times to remove the alcohol (preserving medium).
• Apply the sheet firmly on the wound and remove the air bubbles trapped if any for effective adhesion.
• For best results avoid second dressing over colloskin.
• As epitheliasation occurs, colloskin sheet peels off.
• Colloskin promotes healthy granulation in deep wounds for early grafting.
• Repeated dressing not required unless colloskin is rejected due to underlying pus or complication.
• For skin donor sites, colloskin must be applied after achieving satisfactory hemostasis.
• For chronic skin ulcers, 2 to 3 applications of coloskin or more in 2-3 day intervals must be repeated after thorough cleaning each time, thus enhancing healing.
• In cases where the adhered collokin has to be removed from the wound, a saline, moist pad can be applied over colloskin for a few minutes to facilitate easy removal.

Advantages :Widely accepted for biological wound dressing especially for burns

• Single application on clean wounds.
• Prevents infection
• Instant pain relief
• Quick and firm adherence
• Allows skin to breath
• Preserves local heat
• Stimulates healthy granulation

Sizes available : 5cms x 5cms, 10cms x 10cms, 10cms x 25cms, 15 x30 cms and as per customer requirement.

Diacoll -S^TM is a Collagen Gentamicin Sheet in the form a sponge / Transparant film containing collagen and gentamicin sulphate. The collagen gentamicin implant is composed of highly purified type I collagen obtained from bovine Tendon, which acts as a vehicle for the antimicrobial gentamicin. The collagen is derived from specifically controlled and certified animals and is highly purified to avoid any antiginicity. Gentamicin sulphate is a wide spectrum antibiotic that provides highly effective topical treatment in primary and secondary bacterial infections of the skin. Diacoll -S^TM is produced using the latest triple helix collagen technique to provide an optimum degree of flexibility and rigidity combined with the most predictable resorptive process. Mechanism of Action :Diacoll -S^TM comprises of a collagen foam incoproated with gentamicin sulphate. When applied on the wound the collagen foam acts as a vehicle for the antimicrobial gentamicin. Collagen is absorbed slowly by the tissue in 6 to 10 days after is application. The purpose of the implant is to provide a high concentration of local gentamicin at the site of implantation. The Diacoll -S^TM comes prepacked and sterile and is intended for single use only. Indications :

• Diabetic foot ulcers.
• Orthopedic surgery.
• Treatment of osteomylitis and soft tissue infections.
• Abdominal wound infections.

Directions for use :

• In all cases standard established sterile surgical procedure must be observed.
• Diacoll -S^TM should be cut to the desired size to ideally extend 2-3mm beyond the edge of the defect (s).
• The sheet once wet with blood tends to adapt extremely well to the bone/tissue walls.

Applications of Diacoll -S^TM implant on first day.

• Prepare the wound bed : Change and dispose of the old dressing in a safe, careful and appropriate manner.
• Accomplish appropriate wound debriment.
  • Irrigate the wound gently and carefully with sterile saline water until wound is free of debris, necrotic slough etc.
  • Gently blot wound edges and peri-wound margins dry.
• Apply Diacoll -S^TM
  • Take the appropriate size of the Diacoll -S^TM cut open the sterile pouch.
  • Cut the Diacoll -S^TM According to the shape of the wound and apply it to the wound surface.
  • When applied to the wound surface it tends of adapt extremely well to the bone / tissue walls.
• Wound care dressing : The area may be covered with gauze dressing if desired.

Precautions & Comments :

• Wounds may appear larger during first several days of treatment due to reduction of edema.
• An increase in drainage may be seen in the first several days of treatement.
• Treatment of the underlying conditons (Venous or arterial flow, external pressure as well as nturitional support should proceed concurrently with the use of Diacoll -S^TM.
• Avoid patient hypersensitive to collagen, Gentamicin.
• A transient burning sensation may be experienced by a small percentage of patients.

How supplied : Diacoll -S^TM implant is supplied in the following sizesin a gamma sterilized pouch. Sizes Available : 5cms x 5cms, 10cms x 10cms, 5cms x 20 cms

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