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5-MeO-DMT (5-methoxy-N, N-) is a powerful and relatively obscure psychedelic and entheogen of the tryptamine class. It is found in a wide variety of plant species, as well as in the venom of a single psychoactive toad species (Bufo Alvaris). Like its close relatives DMT and bufotenin (5-HO-DMT), it has been used as an entheogen by South American shamans for thousands of years.[1] In modern times, however, it is primarily acquired in its synthetic powder form through the use of online research chemical vendors. When taken as a drug in its purified or synthetic form, 5-MeO-DMT is vaporized, insufflated, or injected and is active at a dose of as little as 2 mg. 5-MeO-DMT is active orally when taken with an MAOI, but according to numerous reports this combination often tends to be extremely unpleasant and has a strong body load. 5-MeO-DMT or 5-methoxy-N, N-is a ring-substituted indole alkaloid molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicylic indole heterocycle attached at R3 to a terminal amine group via an ethyl side chain. 5-MeO-DMT is substituted at R5 of its indole heterocycle with a methoxy (MeO) functional group CH3O; it also contains two methyl groups CH3- bound to the terminal amine RN of its tryptamine backbone (DMT). 5-MeO-DMT is the N-substituted methyl homologue of 5-MeO-MiPT, although it radically differs in its effects.
4-Acetoxy-N-ethyl-N-methyltryptamine (also known as 4-AcO-MET, Metacetin, and Azomet) is a lesser-known novel psychedelic substance of tryptamine chemical class. Members of this group produce -like psychedelic effects when administered. It is structurally related to psychedelic tryptamines like 4-AcO-DMT, 4-AcO-DET, and 4-AcO-MiPT. 4-AcO-MET is closely related in structure to 4-HO-MET, for which it is theorized to act as a prodrug. 4-AcO-MET is occasionally found in pressed pill which are sold on the streets in northern Switzerland under the name "Acomet" or "Azomet".
4-HO-MiPT, or 4-hydroxy-N-methyl-N-isopropyltryptamine is a lesser-known psychedelic drug. It is also known as Miprocin. It is the 4-hydroxyl analog of MiPT. 4-HO-MiPT was first synthesized by Alexander Shulgin. In his book TIHKAL (Tryptamines I Have Known and Loved), the dosage range is listed as 12-25 mgs, and the duration listed as 4-6 hours, although other sources list the duration as 5-8 hours. 4-HO-MiPT produces vivid and intense closed-eye imagery, enhancement of the senses, time and spatial distortion, and out-of-body experiences. In general, these effects are quite similar to those of the tryptamines, and LSD, though 4-HO-MiPT has less potency. To date, there have been no reports of deaths from 4-HO-MiPT. It is a fairly rare compound with no toxicology
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