With well-connected and substantial warehouse, we arrange the extensive range systematically to deal with urgent deliveries and orders. Our remarkably superior warehouse system helps us in keeping the range safe until the final send off. Staffed with latest machines and leading technology, we make certain that the material we use is as per the stated norms and meet the international standards. Artemisinin has a very rapid action and the vast majority of acute patients treated show significant improvement within 13 days of receiving treatment. It has demonstrated the fastest clearance of all anti-malarials currently used and acts primarily on the trophozite phase, thus preventing progression of the disease. Semi-synthetic artemisinin derivatives (e.g. artesunate, artemether) are easier to use than the parent compound and are converted rapidly once in the body to the active compound dihydroartemesinin. On the first day of treatment 20 mgkg should be given, this dose is then reduced to 10 mgkg per day for the 6 following days. Few side effects are associated with artemesinin use. However, headaches, nausea, vomiting, abnormal bleeding, dark urine, itching and some drug fever have been reported by a small number of patients. Some cardiac changes were reported during a clinical trial, notably non specific ST changes and a first degree atrioventricular block (these disappeared when the patients recovered from the malarial fever).

Pyrimethamine is used in the treatment of uncomplicated malaria. It is particularly useful in cases of chloroquine-resistant P. falciparum strains when combined with sulfadoxine. It acts by inhibiting dihydrofolate reductase in the parasite thus preventing the biosynthesis of purines and pyrimidines, thereby halting the processes of DNA replication, cell division and reproduction. It acts primarily on the schizonts during the erythrocytic phase, and nowadays is only used in concert with a sulfonamide.

Proguanil (chloroguanide) is a biguanide; a synthetic derivative of pyrimidine. It was developed in 1945 by a british antimalarial research group. It has many mechanisms of action but primarily is mediated through conversion to the active metabolite cycloguanil. This inhibits the malarial dihydrofolate reductase enzyme. Its most prominent effect is on the primary tissue stages of p. Falciparum, p. Vivax and p. Ovale. It has no known effect against hypnozoites therefore is not used in the prevention of relapse. It has a weak blood schizonticidal activity and is not recommended for therapy of acute infection. However it is useful in prophylaxis when combined with atovaquone or chloroquine (in areas where there is no chloroquine resistance). 3 mgkg is the advised dosage per day, (hence approximate adult dosage is 200 mg). The pharmacokinetic profile of the drugs indicates that a half dose, twice daily maintains the plasma levels with a greater level of consistency, thus giving a greater level of protection. The proguanil- chloroquine combination does not provide effective protection against resistant strains of p. Falciparum.

Mefloquine was developed during the vietnam war and is chemically related to quinine. It was developed to protect american troops against multi-drug resistant p. Falciparum. It is a very potent blood schizonticide with a long half-life. It is thought to act by forming toxic heme complexes that damage parasitic food vacuoles. It is now used solely for the prevention of resistant strains of p. Falciparum despite being effective against p. Vivax, p. Ovale and p. Marlariae. Mefloquine is effective in prophylaxis and for acute therapy. It is now strictly used for resistant strains (and is usually combined with artesunate). Chloroquineproguanil or sulfa drug-pyrimethamine combinations should be used in all other plasmodia infections.

We provide the most comprehensive listing of bulkdrugs & intermediates manufacturers, suppliers, traders and agents available on the Web. Browse over 2000 companies in over 50 countries or search the directory for bulkdrug manufacturer suppliers by company name, products, CAS No., nation wise search. Doxycycline is probably one of the more prevalent antimalarial drugs prescribed, due to its relative effectiveness and cheapness, doxycycline is a tetracycline compound derived from oxytetracycline. The tetracyclines were one of the earliest groups of antibiotics to be developed and are still used widely in many types of infection. It is a bacteriostatic agent that acts to inhibit the process of protein synthesis by binding to the 30S ribosomal subunit thus preventing the 50s and 30s units from bonding. Doxycycline is used primarily for chemoprophylaxis in areas where chloroquine resistance exists. It can also be used in combination with quinine to treat resistant cases of P. falciparum but has a very slow action in acute malaria, and should not be used as monotherapy.

Being a quality-conscious firm, we consider all the stated quality norms for ensuring that optimum quality products reach the buyers. Ranked among top suppliers of Halofantrine raw material, we can provide the product at economical prices. Halofantrine is a relatively new drug developed by the Walter Reed Army Institute of Research in the 1960s. It is a phenanthrene methanol, chemically related to Quinine and acts acting as a blood schizonticide effective against all Plasmodium parasites. Its mechanism of action is similar to other anti-malarials.

Primaquine our stringent quality procedures and analysis as per the guidelines help us in presenting reliable product range. With the complete help and support of our team members and management, we conduct strict checking on the quality of raw inputs used for manufacturing. Primaquine is a highly active 8-aminoquinolone that is used in treating all types of malaria infection. It is most effective against gametocytes but also acts on hypnozoites, blood schizonticytes and the dormant plasmodia in p. Vivax and p. Ovale. It is the only known drug to cure both relapsing malaria infections and acute cases. The mechanism of action is not fully understood but it is thought to block oxidative metabolism in plasmodia.

Amodiaquine (ADQ) is a medication used to treat malaria, including Plasmodium falciparum malaria when uncomplicated.It is recommended to be given with artesunate to reduce the risk of resistance.Due to the risk of rare but serious side effects, it is not generally recommended to prevent malaria. The side effects of amodiaquine are generally minor to moderate and are similar to those of chloroquine.Rarely liver problems or low blood cell levels may occur.When taken in excess headaches, trouble seeing, seizures, and cardiac arrest may occur.While not extensively studied as of 2007, it appeared to be safe in pregnancy.Amodiaquine is a 4-aminoquinoline compound related to chloroquine.

Our all apis produced out of premium grade supplies, our entire range is quality assured and conforms to global industry standards. Buyers prefer us for our practice of delivering the orders within the pre-decided time frame

With well-connected and substantial warehouse, we arrange the extensive range systematically to deal with urgent deliveries and orders. Our remarkably superior warehouse system helps us in keeping the range safe until the final send off. Staffed with latest machines and leading technology, we make certain that the material we use is as per the stated norms and meet the international standards. Artemisinin has a very rapid action and the vast majority of acute patients treated show significant improvement within 13 days of receiving treatment. It has demonstrated the fastest clearance of all anti-malarials currently used and acts primarily on the trophozite phase, thus preventing progression of the disease. Semi-synthetic artemisinin derivatives (e.g. artesunate, artemether) are easier to use than the parent compound and are converted rapidly once in the body to the active compound dihydroartemesinin. On the first day of treatment 20 mgkg should be given, this dose is then reduced to 10 mgkg per day for the 6 following days. Few side effects are associated with artemesinin use. However, headaches, nausea, vomiting, abnormal bleeding, dark urine, itching and some drug fever have been reported by a small number of patients. Some cardiac changes were reported during a clinical trial, notably non specific ST changes and a first degree atrioventricular block (these disappeared when the patients recovered from the malarial fever).

Pyrimethamine is used in the treatment of uncomplicated malaria. It is particularly useful in cases of chloroquine-resistant P. falciparum strains when combined with sulfadoxine. It acts by inhibiting dihydrofolate reductase in the parasite thus preventing the biosynthesis of purines and pyrimidines, thereby halting the processes of DNA replication, cell division and reproduction. It acts primarily on the schizonts during the erythrocytic phase, and nowadays is only used in concert with a sulfonamide.

Proguanil (chloroguanide) is a biguanide; a synthetic derivative of pyrimidine. It was developed in 1945 by a british antimalarial research group. It has many mechanisms of action but primarily is mediated through conversion to the active metabolite cycloguanil. This inhibits the malarial dihydrofolate reductase enzyme. Its most prominent effect is on the primary tissue stages of p. Falciparum, p. Vivax and p. Ovale. It has no known effect against hypnozoites therefore is not used in the prevention of relapse. It has a weak blood schizonticidal activity and is not recommended for therapy of acute infection. However it is useful in prophylaxis when combined with atovaquone or chloroquine (in areas where there is no chloroquine resistance). 3 mgkg is the advised dosage per day, (hence approximate adult dosage is 200 mg). The pharmacokinetic profile of the drugs indicates that a half dose, twice daily maintains the plasma levels with a greater level of consistency, thus giving a greater level of protection. The proguanil- chloroquine combination does not provide effective protection against resistant strains of p. Falciparum.

Mefloquine was developed during the vietnam war and is chemically related to quinine. It was developed to protect american troops against multi-drug resistant p. Falciparum. It is a very potent blood schizonticide with a long half-life. It is thought to act by forming toxic heme complexes that damage parasitic food vacuoles. It is now used solely for the prevention of resistant strains of p. Falciparum despite being effective against p. Vivax, p. Ovale and p. Marlariae. Mefloquine is effective in prophylaxis and for acute therapy. It is now strictly used for resistant strains (and is usually combined with artesunate). Chloroquineproguanil or sulfa drug-pyrimethamine combinations should be used in all other plasmodia infections.

We provide the most comprehensive listing of bulkdrugs & intermediates manufacturers, suppliers, traders and agents available on the Web. Browse over 2000 companies in over 50 countries or search the directory for bulkdrug manufacturer suppliers by company name, products, CAS No., nation wise search. Doxycycline is probably one of the more prevalent antimalarial drugs prescribed, due to its relative effectiveness and cheapness, doxycycline is a tetracycline compound derived from oxytetracycline. The tetracyclines were one of the earliest groups of antibiotics to be developed and are still used widely in many types of infection. It is a bacteriostatic agent that acts to inhibit the process of protein synthesis by binding to the 30S ribosomal subunit thus preventing the 50s and 30s units from bonding. Doxycycline is used primarily for chemoprophylaxis in areas where chloroquine resistance exists. It can also be used in combination with quinine to treat resistant cases of P. falciparum but has a very slow action in acute malaria, and should not be used as monotherapy.

Being a quality-conscious firm, we consider all the stated quality norms for ensuring that optimum quality products reach the buyers. Ranked among top suppliers of Halofantrine raw material, we can provide the product at economical prices. Halofantrine is a relatively new drug developed by the Walter Reed Army Institute of Research in the 1960s. It is a phenanthrene methanol, chemically related to Quinine and acts acting as a blood schizonticide effective against all Plasmodium parasites. Its mechanism of action is similar to other anti-malarials.

Primaquine our stringent quality procedures and analysis as per the guidelines help us in presenting reliable product range. With the complete help and support of our team members and management, we conduct strict checking on the quality of raw inputs used for manufacturing. Primaquine is a highly active 8-aminoquinolone that is used in treating all types of malaria infection. It is most effective against gametocytes but also acts on hypnozoites, blood schizonticytes and the dormant plasmodia in p. Vivax and p. Ovale. It is the only known drug to cure both relapsing malaria infections and acute cases. The mechanism of action is not fully understood but it is thought to block oxidative metabolism in plasmodia.

Amodiaquine (ADQ) is a medication used to treat malaria, including Plasmodium falciparum malaria when uncomplicated.It is recommended to be given with artesunate to reduce the risk of resistance.Due to the risk of rare but serious side effects, it is not generally recommended to prevent malaria. The side effects of amodiaquine are generally minor to moderate and are similar to those of chloroquine.Rarely liver problems or low blood cell levels may occur.When taken in excess headaches, trouble seeing, seizures, and cardiac arrest may occur.While not extensively studied as of 2007, it appeared to be safe in pregnancy.Amodiaquine is a 4-aminoquinoline compound related to chloroquine.

Our all apis produced out of premium grade supplies, our entire range is quality assured and conforms to global industry standards. Buyers prefer us for our practice of delivering the orders within the pre-decided time frame