Category: AnticancerEach vial contains:-Carboplatin. 150mg , 450 mg and 600 mgQuality Specification:Chromatographic Purity: NLT 99.5% It is a platinum coordination complex. It causes cross linking of DNA; favoured site being N7 of guanine residue. It can also react with SH groups in proteins and has radiomimetic property. It is bound to plasma proteins, enters, tissues & is slowly excreted unchanged in urine. Cisplatin is very effective in metastatic testicular & ovarian carcinoma. It has found use in some other solid tumours as well.Composition : 150mg, /15ml, 450mg/45mlIndication : Metastatic testicular and overian carcinoma, advanced bladder, Head & neck cancer.Dosage :- Admin by slow infusion 10-60 mg or as required.Contra Indications :- Pregnancy, lactation hypersensitivity, renal impairment.Special Precautions :- Maintain good hydration. Shock like state sometimes occurs during i.v. infusion, . Monitor haematological, neurological status & renal functions. Hypomagnesaemia. Hypocalcaemia. Hyperuricaemia.Paediatrics : Not usually prescribed. The risk of hearing loss is increased.Pregnancy :- Not usually prescribed.Lactation :- Not advised.Elderly :- Reduced dose may be necessary.Side Effects :- Nausea, vomiting, Tinnitus, deafness, neuropathy, nephrotoxicity, electrolyte imbalance.Drug Interactions :- Potentiates neurotoxicity with aminoglycosides. Ideal combination with other cytotoxic drugs. Synergistic with 5-fluorouracil and etoposide.Purity : Not less than 99%. Facility - WHO-GMP
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V. K. Saxena (Apollo Life Sciences Pvt Ltd)
B/134, Oshiwara Industrial Centre Oop Oshiwara Bus Depot, New Link Road, Goregoan West Mumbai : 400 104 India., Maharashtra - 400104
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