Our Products
Our product range contains a wide range of Diabetes Medicines, Citicoline, THALIDOMIDE CAPSULES USP 50, 100,200 MG, EMLA CREAM and Veenat Tablet
For effective and optimum quality Diabetes Medicines, you can contact us. We are trusted Supplier and Exporter of Diabetes Medicines from Maharashtra. These Diabetes Medicines are highly acclaimed for their accurate composition and effectiveness. We source the Diabetes Medicines from authorized pharmaceutical companies only. All the Diabetes Medicines are offered in excellent quality packaging. Customers can purchase the Medicines at market leading rates.
immunomodulatory agent.
DESCRIPTION
Thalidomide Capsules USP 50, 100, 200 mg is an immunomodulatory agent.It is used in treatment of
MULTIPLE MYELOMAThalidomide Capsules in combination with dexamethasone is indicated for the treatment of patients with newly diagnosed multiple myeloma (MM).
ERYTHEMA NODOSUM LEPROSUMThalidomide Capsules is indicated for the acute treatment of the cutaneous manifestations of moderate to severe erythema nodosum leprosum (ENL). THALOMID is not indicated as monotherapy for such ENL treatment in the presence of moderate to severe neuritis. THALOMID is also indicated as maintenance therapy for prevention and suppression of the cutaneous manifestations of ENL recurrence.
There are many generic manufacturers in India who manufacture Thalidomide Capsules USP 50, 100, 200 mg including United Biotech (p) Limited etc.
3s corporation is Supplier, Exporter , Wholesaler for Thalidomide Capsules USP 50, 100, 200 mg in India.
SIDE EFFECTS
Side effects include
We are involved in offering EMLA Cream. The cream is formulated using quality-approved chemical compounds. Bulk orders of the cream are processed by us as per the specific requirements of the buyers.
Altraz 1mg also known as Anastrozole is a prescription drug used to treat early breast cancer in women who have experienced menopause. Altraz (1mg) is also used to treat breast cancer that has spread within the breast or to other areas of the body. As Altraz contains Anastrozole, it works by reducing the amount of the hormone called oestrogen in your body, by blocking an enzyme called ‘aromatase’.
Manufacturer : Alkem Laboratories Ltd
ADDITIONAL INFORMATION
Strengths available : 1mg
Storage : Store at temperature between 20 °C – 25 °C
Dosage : 1 mg orally taken once a day
Patient Advice:
-If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the next regularly scheduled dose. Do not take 2 doses at the same time.
SIDE EFFECTS
Most common side effects are Headache, Hot flushes, Nausea, Skin rash, Musculoskeletal (bone, muscle or joint) pain, Osteoporosis, Weakness.
Bicalutamide Tablets, USP 50 mg are an androgen receptor inhibitor indicated for use in combination therapy with a luteinizing hormone-releasing hormone (LHRH) analog for the treatment of Stage D2 metastatic carcinoma of the prostate.Treatment with bicalutamide should be started at least 3 days before commencing treatment with an LHRH analogue, or at the same time as surgical castration.
India has many manufacturers locally who manufacture Bicalutamide tablets. To know more, contact us.
The recommended dose for Bicalutamide Tablets, USP therapy in combination with an LHRH analog is one 50 mg tablet once daily (morning or evening).The tablets should be swallowed whole with liquid.
Body as a Whole: neoplasm; neck pain; fever; chills; sepsis; hernia; cyst
Cardiovascular: angina pectoris; congestive heart failure; myocardial infarct; heart arrest; coronary artery disorder; syncope
Digestive: melena; rectal hemorrhage; dry mouth; dysphagia; gastrointestinal disorder; periodontal abscess; gastrointestinal carcinoma
Metabolic and Nutritional: edema; BUN increased; creatinine increased; dehydration; gout; hypercholesteremia
Musculoskeletal: myalgia; leg cramps
Nervous: hypertonia; confusion; somnolence; libido decreased; neuropathy; nervousness
Respiratory: lung disorder; asthma; epistaxis; sinusitis
Skin and Appendages: dry skin; alopecia; pruritus; herpes zoster; skin carcinoma; skin disorder
Special Senses: cataract specified
Urogenital: dysuria; urinary urgency; hydronephrosis; urinary tract disorder
Severe hepatic changes and hepatic failure have been observed rarely. Monitor serum transaminase levels prior to starting treatment with Bicalutamide Tablets, USP, at regular intervals for the first four months of treatment and periodically thereafter, and for symptoms or signs suggestive of hepatic dysfunction. Use Bicalutamide Tablets, USP with caution in patients with hepatic impairment.
Capecitabine is a fluoropyrimidine carbamate withantineoplasticactivity. It is an orally administered systemicprodrugof 5-deoxy-5-fluorouridine (5-DFUR) which is converted to 5-fluorouracil.The chemical name for capecitabine is 5-deoxy-5-fluoro-N-[(pentyloxy) carbonyl]-cytidine.Capecitabine is a cancer medication that interferes with the growth of cancer cells and slows their spread in the body.Capecitabine is used to treat breast cancer and colon or rectum cancer that has spread to other parts of the body.Capecitabine is often used in combination with other cancer medications and/or radiation treatments.
It is manufactured by many Indian manufacturers . 3scorporation is supplier, exporter, wholesaler for Capecitabine Tablets in India.
ADDITIONAL INFORMATIONYou should not take this medication if you are allergic to capecitabine or fluorouracil (Adrucil), or if you have severe kidney disease or a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency.
Before you take capecitabine, tell your doctor if you have liver or kidney disease, a history of coronary artery disease, or if you are also taking folic acid (contained in many vitamin and mineral supplements), leucovorin (Wellcovorin), phenytoin (Dilantin), or a blood thinner (warfarin, Coumadin).
SIDE EFFECTSCall your doctor at once if you have a serious side effect such as:
Imatib ( imatinib) 400 mg manufactured by Cipla
Imatib is used for the treatment of a type of leukemia (chronic myeloid leukemia or CML), gastrointestinal stromal tumors (GISTs – a type of tumor that grows in the walls of the digestive passages and may spread to other parts of the body). Imatib may also be used to prevent cancer from growing in patients after surgical removal of GIST. Imatib is also used for the treatment of dermatofibrosarcoma protuberans (a tumor that forms under the top layer of skin) when the tumor cannot be removed surgically, has spread to other parts of the body, or has come back after surgery.
Imatib (Imatinib) is used to prevent and stop the growth of cancer cells of some types of myeloid leukemia and gastrointestinal stromal tumors. This medicine helps your body to stop making abnormal cells which cause the tumors to grow
Tobacco, grapefruit juice, and alcohol may interact with Imatib (Imatinib). Take Imatib (Imatinib) strictly as directed by your physician, with a glass of water and a meal.
SIDE EFFECTS
As with all medications, Imatib (Imatinib) has the potential to cause side effects in some patients. Common side effects include indigestion, an acid stomach, belching, feeling full or bloated, feeling empty, sad, or unusually cold, having difficulty moving, sleeplessness, stiff muscles, loose stools, unexplained weight loss, passing gas, a lack of interest or loss of pleasure in things, belching, and heartburn. If these symptoms worsen or persist contact your physician.
Thalix (Thalidomide) useful to treat the multiple myeloma. Patients who are diagnosed with this disease at an earlier stage can most benefit from this medication. Thalix can be consumed alone or combined with other medications like dexamethasone for the treatment and prevention of skin inflammation in the patients of erythema nodosum leprosum or ENL.
Specifications:
NOTE : Thalix is a prescription drug and should be used under proper medical guidance and advice. Do not share the medicine with others, since they may be suffering from a problem that is not effectively treated by this drug.
DESCRIPTION
Xeloda 500 mg (Capecitabine) is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. Xeloda is classified as an ‘antimetabolite’. There are also many cheaper generic medicines available in India as a replacement for Xeloda.
What Xeloda Is Used For:
How Xeloda Is Given:
Taken as a pill by mouth.Take after food (within 30 minutes of a meal) with water. (Usually taken in a divided dose 12 hours apart).Tablets come in 2 sizes; 150mg and 500mg.Do not crush, chew or dissolve tablets.The amount of Xeloda that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated. Your doctor will determine your dose and schedule.
Xeloda Side Effects:
These Xeloda side effects are less common side effects (occurring in about 10-29%) of patients receiving Xeloda:
Vancomycin Hydrochloride Injection 500 & 1000 mg is a tricyclic glycopeptide antibiotic derived from Amycolatopsis orientalis .Vancomycin is indicated for the treatment of serious or severe infections caused by susceptible strains of methicillin-resistant (beta-lactam-resistant) staphylococci. It is indicated for penicillin-allergic patients, for patients who cannot receive or who have failed to respond to other drugs, including the penicillins or cephalosporins .Vancomycin is indicated for initial therapy when methicillinresistant staphylococci are suspected, but after susceptibility data are available, therapy should be adjusted accordingly.Vancomycin is effective in the treatment of staphylococcal endocarditis. Its effectiveness has been documented in other infections due to staphylococci, including septicemia , bone infections, lower respiratory tract infections, skin and skin structure infections. When staphylococcal infections are localized and purulent, antibiotics are used as adjuncts to appropriate surgical measures.
India has many manufacturers who manufacture Vancomycin Hydrochloride Injection 500 & 1000 mg .To know more contact us.
3s corporation is Supplier, Exporter , Wholesaler for Vancomycin Hydrochloride Injection 500 & 1000 mg in India.
ADDITIONAL INFORMATION
Rapid bolus administration (e.g., over several minutes) may be associated with exaggerated hypotension, including shock, and, rarely, cardiac arrest. Vancomycin should be administered over a period of not less than 60 minutes to avoid rapid-infusion-related reactions. Stopping the infusion usually results in prompt cessation of these reactions.
SIDE EFFECTS
During or soon after rapid infusion of vancomycin, patients may develop anaphylactoid reactions, including hypotension, wheezing, dyspnea, urticaria. Rapid infusion may also cause flushing of the upper body
NEPHROTOXICITYRenal failure, principally manifested by increased serum creatinine or BUN concentrations, especially in patients administered large doses of vancomycin, has been reported rarely.
GASTROINTESTINALOnset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment .
OTOTOXICITYA few dozen cases of hearing loss associated with vancomycin have been reported. Most of these patients had kidney dysfunction or a preexisting hearing loss or were receiving concomitant treatment with an ototoxic drug.
PHLEBITISInflammation at the injection site has been reported.
Famotidine Injection 20 mg Injection (famotidine injection) are indicated in some hospitalized patients with pathological hypersecretory conditions or intractable ulcers, or as an alternative to the oral dosage forms for short term use in patients who are unable to take oral medication for the conditions such as Short term treatment of active duodenal ulcer, Maintenance therapy for duodenal ulcer patients at reduced dosage after healing of an active ulcer and Short term treatment of active benign gastric ulcer.
3s corporation is Supplier, Exporter , Wholesaler for Famotidine Injection 20 mg in India.
We even offer contract manufacturing services from WHO GMP approved factories.
SIDE EFFECTS
Body as a Whole:Fever, asthenia, fatigue.
Cardiovascular: arrhythmia, AV block, palpitation
Gastrointestinal: cholestatic jaundice, liver enzyme abnormalities, vomiting, nausea, abdominal discomfort, anorexia, dry mouth.
Musculoskeletal: musculoskeletal pain including muscle cramps, arthralgia.
Nervous System/Psychiatric: grand mal seizure; psychic disturbances, which were reversible in cases for which follow-up was obtained, including hallucinations, confusion, agitation, depression, anxiety, decreased libido;paresthesia; insomnia; somnolence. Convulsions, in patients with impaired renal function, have been reported very rarely.
Respiratory: bronchospasm, interstitial pneumonia
Skin: toxic epidermal necrolysis/Stevens Johnson syndrome (very rare), acne, dry skin, flushing
Special Senses: tinnitus, taste disorder
Paracoxib sodium Injection 40 mg belongs to a group of medicines called COX-2 inhibitors. It is used to help relieve pain after certain types of surgical procedures.
Parecoxib sodium works by reducing the production of chemicals in the body called prostoglandins (pros-to-glan-dins). Prostoglandins are involved in controlling inflammation and pain. By reducing the production of prostoglandins parecoxib sodium can help to reduce pain and inflammation after surgery.
3s corporation is Supplier, Exporter , Wholesaler for Paracoxib sodium Injection 40 mg in India.
India has many manufacturers who manufacture Paracoxib sodium Injection 40 mg .To know more contact us.
SIDE EFFECTS
Glizid (Gliclazide) tablet from Panacea is used to help control blood sugar levels in people with type 2 diabetes. This medicine is prescribed when blood sugar levels cannot be controlled by diet, exercise, and weight loss measures alone. Available in 40 & 80 mg dosage.
Onglyza (Saxagliptin) manufactured by Bristol Myers Squibb is an oral medicine used to treat people with type 2 diabetes (non-insulin-dependent diabetes). Onglyza (saxagliptin) is a prescription medicine used along with diet and exercise to lower blood sugar in adults with type 2 diabetes.It should not be used to treat people with type 1 diabetes or diabetic ketoacidosis (increased ketones in the blood or urine). If you have had inflammation of the pancreas (pancreatitis), it is not known if you have a higher chance of getting pancreatitis while taking it.
This medicine helps control blood sugar levels, which is used in combination with a proper diet and exercise program. Controlling of high blood sugar levels helps prevent kidney damage, blindness, nerve problems, and sexual function problems. Onglyza (Saxagliptin) works by regulating the insulin levels of the body after eating food.
ADDITIONAL INFORMATION
Recommended Dosage – Discount Prescription Drug Onglyza (Saxagliptin)
The dosage of Onglyza (Saxagliptin) prescribed to each patient will vary. Always follow your physician’s instructions and/or the directions on the prescription drug label.
Onglyza (Saxagliptin) can be taken with or without food.
Missed Dose of Onglyza (Saxagliptin)
If your physician has instructed or directed you to take Onglyza (Saxagliptin) medication in a regular schedule and you have missed a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, then skip the missed dose and go back to your regular dosing schedule. Do not double the doses unless otherwise directed.
Overdose of Onglyza (Saxagliptin)
Any medication taken in excess can have serious consequences. If you suspect an overdose of Onglyza (Saxagliptin), seek medical attention immediately.
SIDE EFFECTS
Side Effects of Onglyza:
Like other medicines, Onglyza (Saxagliptin) can cause some side effects. If they do occur, the side effects of Onglyza (Saxagliptin) are most likely to be minor and temporary. However, some may be serious and may require the individual to inform the doctor or visit the nearest hospital immediately.
It is pertinent to note that side effects of Onglyza (Saxagliptin) cannot be anticipated. If any side effects of Onglyza (Saxagliptin) develop or change in intensity, the doctor should be informed as soon as possible.
Onglyza (Saxagliptin) can cause side effects such as headache, stomach pain, cough, sore throat and runny nose. This is not a complete list of all side effects. Do concur with your doctor and follow his directions completely when you are taking Onglyza (Saxagliptin).
Drug Interaction :
Usually drug interactions occur when it is taken with another drug or with food. Before you take a medication for a particular ailment, you should inform the health expert about intake of any other medications including non-prescription medications, over-the-counter medicines that may increase the effect of Onglyza (Saxagliptin), and dietary supplements like vitamins, minerals and herbal, so that the doctor can warn you of any possible drug interactions.
Onglyza (Saxagliptin) can interact with antidepressants, antifungal medications, and blood pressure medications.
Also, tell your prescriber or health care professional if you are a frequent user of drinks containing caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.
Cymevene 500 mg , Generic name : GANCICLOVIR , Manufacturer : Roche
Cymevene belongs to a group of medicines called ‘anti-virals’. Cymevene is used to treat infections caused by a virus called cytomegalovirus (CMV) in people who have received organ or bone marrow transplants and this can affect any part of the body including retina . Cymevene Vial (Ganciclovir) 500mg is also used to treat people with weakened immune systems (including people with AIDS) who have CMV retinitis. Cymevene Vial (Ganciclovir) 500mg works by slowing the growth of the CMV virus. It helps control CMV retinitis and decrease the risk of blindness. It also helps prevent the spread of infection to other areas of the body.
Usage : Cymevene Vial (Ganciclovir) 500mg is given by injection into a vein usually over a 1-hour period
Side effects Cymevene Vial (Ganciclovir) 500mg may cause Diarrhea, upset stomach, dizziness, drowsiness, unsteadiness, shaking (tremors), or pain/redness/irritation at the injection site may occur
Capegard 500mg (Capecitabine) Tablet is a prescription drug used in the treatment of Ovarian cancer, Cervical cancer, Head and neck cancer. The medication works by interfering with the growth of DNA and RNA of the cancer cells and thereby prevents it from growing and multiplying and also helps in decreasing tumor size.
ADDITIONAL INFORMATION
Strengths available : 500mg
Storage : Store in a cool dry place. Protect from light.
Dosage :
CAPEGARD 500 Tablets should be swallowed whole with water within 30 minutes after a meal. The dose of CAPEGARD 500 Tablets is calculated according to the body surface area.
Standard Starting Dose
Monotherapy (Metastatic Colorectal Cancer, Adjuvant Colorectal Cancer, Metastatic Breast Cancer)
The recommended dose of CAPEGARD 500 Tablets is 1, 250 mg/m2 administered orally twice daily (morning and evening; equivalent to 2, 500 mg/m2 total daily dose) for 2 weeks followed by a 1-week rest period; the tablets are given as 3-week cycles
SIDE EFFECTS
Most common side effects are Nausea, Vomiting, Weakness, Abdominal pain, Loss of appetite, Fatigue, Diarrhoea, Hand-foot syndrome, Stomatitis (Inflammation of the mouth).
IGWOK also known as Human Normal Immunoglobulin, is a plasma protein which works by increasing plasma volume or albumin level in the blood during surgery, dialysis, abdominal infections, liver failure, pancreatitis, bypass surgery and many other conditions. It is used to replace blood loss due to trauma or any other injuries that caused blood loss.
Dosage
Prophylaxis of infections after bone marrow transplantation :
Adult: 500 mg/kg/weeks, adjust dose according to response.
Raise platelet count in patients with idiopathic thrombocytopenic purpura :
Adult: 400 mg/kg/day for 2-5 consecutive days. Alternatively, a dose of 800-1000 mg/kg may be given on day 1 and repeated on day 3 if needed. Doses to be given via IV infusion. Treatment may be repeated if relapse occurs.
Kawasaki disease
Adult: 1.6-2 g/kg in divided doses over 2-5 days, or 2 g/kg given as a single dose. To be used in conjunction with acetylsalicylic acid.
Guillain-Barre syndrome :
Adult: 400 mg/kg daily for 5 consecutive days, may repeat every 4 weeks if needed.
SIDE EFFECTS
Common side effects are Dizziness, light-headedness, nausea, vomiting, allergic and cutaneous reactions. Local pain and tenderness at the site of inj. IV admin may lead to systemic effects such as headache, chills and fever.
PiCASA 40mg also known as Posaconazole is an antifungal medication prevents fungal infections in patients who have a weak immune system due to certain treatments or conditions like chemotherapy, stem cell transplantation, HIV infection, and others.
Dosage :
Dosage for Aspergillosis – Invasive
IV:
Oral:
Delayed-release tablets:
Oral suspension: 200 mg orally three times a day
Duration of therapy: Should be based on recovery from immunosuppression or neutropenia
SIDE EFFECTS
Most common side effects are Headache, chest pain, dizziness, pale skin, easy bruising or bleeding, rapid heart rate, trouble concentrating, nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, extreme thirst, increased urination, leg discomfort
Cacit 500mg Tablet (Capecitabine) is prescription drug used in the treatment of ovarian cancer, head and neck cancer, cervical cancer, colorectal and breast cancer. It inhibits the growth of DNA and RNA of the cancer cells by substituting their building blocks and thereby prevents the cancer cells from growing and multiplying.
Recommended Dose: 1250 mg/m2 orally 2 times a day (morning and evening; equivalent to 2500 mg/m2 total daily dose) for 2 weeks followed by a 1 week rest period given as 3 week cycles.
SIDE EFFECTS
Most common side effects are Nausea, Vomiting, Weakness, Abdominal pain, Loss of appetite, Fatigue, Diarrhoea, Hand-foot syndrome, Stomatitis (Inflammation of the mouth).
We are offering Tykerb Tablets that are used for treating breast cancer. We procure Tykerb Tablets from the leading manufacturers, Glaxosmith. Used with capecitabine (Xeloda) or letrozole (Femara), the Tykerb Tablets are appreciated for showing optimum results in cancer patients. Tykerb Tablets should be consumed on empty stomach. Only prescribe dosage of these tablets is recommended.
Important information about Tykerb :
Before taking Tykerb :
An electrolyte imbalance (such as low levels of potassium or magnesium in your blood) ; A personal or family history of “long qt syndrome.”
Arimidex 1 mg Tablets (generic name Anastrozole) that we provide are an aromatase-inhibiting drug used for the treatment of breast cancer after surgery as well as for metastasis in both pre & post-menopausal women. Arimidex 1 mg Tablets lower down the estrogen levels in postmenopausal women, which ultimately slow the growth of certain types of breast tumors. It is usually given to women whose cancer has progressed even after taking tamoxifen (Nolvadex, Soltamox).
ARIMIDEX is supplied in 30 tablets/bottle . Please take your medication as prescribed by your doctor.
General Tips for Taking Arimidex :
Get emergency medical help if you have any of these signs of an allergic reaction to Arimidex :
Call Your Doctor At Once if You have :
Side Effects May Include :
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Manufacturer : Astra Zeneca
We are reckoned as one of the prime Exporters and Suppliers of Thalix 50 mg Capsules. Useful in treating multiple myeloma, the Thalix 50 mg Capsules can be consumed alone or combined with other medications. They should be consumed under proper medical guidance and advice only. Available at the best market prices, the Thalix 50 mg Capsules are hygienically packed in premium blister packaging.
Bicalutamide Tablets are essentially a hormone therapy that is classified under anti-androgen. These Bicalutamide Tablets are often prescribed along with LHRH agonist in a combination for effective results. Bicalutamide Tablets should be taken under the supervision of a medical practitioner. We offer Bicalutamide Tablets in blister packing.
Drug Class and Mechanism :
Noxafil 200 mg Oral Suspension is an antifungal medicine formulated by Merck and is used to fight certain infections caused by fungus. It is used by people with weak immune system to prevent various kinds of fungal infections. Noxafil 200 mg Oral Suspension is also used to treat oral thrush. It comes in 200 mg/ 5ml (40 mg per ml) in 105 ml. We are counred among the leading Suppliers and Exporters of Noxafil 200 mg Oral Suspension from Maharashtra, India.
Addtional Information : Noxafil injection must be administered through an in-line filter. Administer by intravenous infusion over approximately 90 minutes via a central venous line. Never give Noxafil injection as an intravenous bolus injection.
Side Effects : Common treatment-emergent adverse reactions in studies with posaconazole are diarrhea, nausea, fever, vomiting, headache, coughing, and hypokalemia.
Packing : 105 ml
The company is engaged in making available Anastrozole Tablets. The tablets offered by us are formulated in neat and hygienic conditions under the guidance of experts. One can obtain these at nominal rates from us.
Description : Anastrozole tablets for oral administration contain 1 mg of anastrozole, a non-steroidal aromatase inhibitor.Anastrozole is used to treat breast cancer in postmenopausal women. It is often given to women whose cancer has progressed even after taking tamoxifen (Nolvadex, Soltamox). It is a non-steroidal aromatase inhibitor. This medication is available in generic form.
Urokinase Injection 500000 IU is used in intravascular lysis of blood clots in the conditions such as extensive acute proximal deep vein thrombosis, acute massive pulmonary embolism, acute occlusive peripheral arterial disease with limb threatening ischemia, thrombosed arteriovenous haemodialysis shunts and thrombosed central venous catheters.
India has many manufacturers who manufacture Urokinase Injection 500000 IU .To know more contact us.
3s corporation is Supplier, Exporter , Wholesaler for Urokinase Injection 500000 IU in India.
SIDE EFFECTS
Haemorrhage
The most frequent and severe side effect of urokinase therapy is haemorrhage. The haemostatic status of the patient may be more profoundly altered with urokinase therapy than with heparin or coumarin-derivative anticoagulant therapy.
Severe spontaneous bleeding, including fatalities resulting from cerebral haemorrhage, has occurred during urokinase therapy. Less severe spontaneous bleeding has occurred approximately twice as frequently as that occurring during heparin therapy. Patients with pre-existing haemostatic defects have the greatest risk of spontaneous bleeding.
Hypersensitivity reactions
In contrast to streptokinase, urokinase is reportedly non-antigenic. However, mild allergic reactions including bronchospasm and rash have been reported rarely. In addition, very rare cases of fatal anaphylaxis have been reported.
Infusion reactions
Fever and chills, including shaking chills (rigors), have been reported occasionally in patients receiving urokinase. Symptomatic treatment is usually sufficient to alleviate discomfort caused by urokinase-induced fever; however, acetylsalicylic acid should not be used.
Other infusion reactions reported with urokinase therapy include dyspnoea, cyanosis, hypoxemia, acidosis, back pain, and nausea and/or vomiting; these effects reactions generally occurred within one hour of beginning urokinase infusion.